| Abstract: | It is shown that several chemical transformations, well known from the chemistry of lysergic acid, can be applied to derivatives of 6-methyl-8-ergolene. Under suitable conditions no appreciable rearrangement to the corresponding 9-ergolene derivatives (lysergic acid derivatives) is observed. These transformations include preparation of amides via the acyl-chloride, alkylation of the free acid and of its amides in position 1, bromination in position 2 and reduction of the aminocarbonyl group by means of LiAlH4. Some investigations about the stability of 8-ergolene derivatives with regard to rearrangement to 9-ergolenes are reported. |
