Formal enantioselective total synthesis of schulzeines A-C via Pd-catalyzed intramolecular asymmetric allylic amination |
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Authors: | Lin Chi-Feng Ojima Iwao |
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Institution: | Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York 11794-3400, USA. |
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Abstract: | Formal enantioselective total synthesis of schulzeines A-C was accomplished, featuring highly efficient Pd-catalyzed asymmetric allylic amination using novel diphosphonite ligands (BOPs) to provide 1-vinyltetrahydroisoquinoline key intermediates, as well as Ru-catalyzed ring-closing metathesis reaction to construct the key tricyclic cores in enantiopure form with correct absolute configurations. |
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