PHOTOREACTION OF 8-METHOXYPSORALEN WITH THYMIDINE |
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| Authors: | Sang Chul Shim Yong Zu Kim |
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| Institution: | Department of Chemistry, Korea Advanced Institute of Science and Technology, P.O. Box 150, Chongyangni, Seoul 131, Korea |
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| Abstract: | Abstract— The photoreaction of 8-methoxypsoralen (8-MOP) with thymidine in solid film state yielded two 4', 5'-monoadducts (a pair of diastereomers) and three 3,4-monoadducts. The stereochemistry of two 4', 5'-monoadducts was found to be cis-syn and trans-syn and one 3,4-monoadduct was cis-anti. In addition to these monoadducts, 3,4-, 4', 5'-biadducts were also formed during the reaction, but the isolation of each isomer of these adducts was not successful; however, the formation of these biadducts was confirmed by UV, IR, TLC and photosplitting experiments. |
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