Application of the Dakin-West reaction for the synthesis of oxazole-containing dual PPARalpha/gamma agonists |
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| Authors: | Godfrey Alexander G Brooks Dawn A Hay Lynne A Peters Mary McCarthy James R Mitchell David |
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| Affiliation: | Lilly Research Laboratories, Eli Lilly & Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA. agg@lilly.com |
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| Abstract: | An improved method for the preparation of a series of oxazole-containing dual PPARalpha/gamma agonists is described. A synthetic sequence utilizing a Dakin-West reaction was devised that allows for the introduction of the oxazole ring either late in the synthetic sequence via aminomalonate-derived chemistry or in pivotal SAR intermediates derived from aspartic acid. |
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