| 支链淀粉-三(苯基氨基甲酸酯)手性固定相的制备及酸性外消旋药物联苯双酯的拆分 |
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| 引用本文： | 周志强,丁二润,侯经国,蒋生祥,陈立仁.支链淀粉-三(苯基氨基甲酸酯)手性固定相的制备及酸性外消旋药物联苯双酯的拆分[J].分析测试学报,1998(5). |
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| 作者姓名： | 周志强 丁二润 侯经国 蒋生祥 陈立仁 |
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| 作者单位： | 中国科学院兰州化学物理研究所 |
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| 基金项目： | 中国科学院重点项目基金 |
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| 摘 要： | 合成并制备了支链淀粉－三（苯基氨基甲酸酯）手性固定相，利用高效液相色谱首次拆分了酸性外消旋药物联苯双酯，考察了流动相中异丙醇含量对拆分的影响。
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| 关 键 词： | 高效液相色谱，支链淀粉－三（苯基氨基甲酸酯），外消旋药物，手性拆分 |
Enantiometric Resolution of Racemic Biphenyl Diesters of Acidic Drugs Using Amylopectin-tris(Phenylcarbamate) as Chiral Stationary Phase |
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| Zhou Zhiqiang,Ding Errun,Hou Jingguo,Jiang Shengxiang,Chen Liren.Enantiometric Resolution of Racemic Biphenyl Diesters of Acidic Drugs Using Amylopectin-tris(Phenylcarbamate) as Chiral Stationary Phase[J].Journal of Instrumental Analysis,1998(5). |
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| Authors: | Zhou Zhiqiang Ding Errun Hou Jingguo Jiang Shengxiang Chen Liren |
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| Abstract: | Amylopectin_tris(phenylcarbamate) was synthesized and used as a chiral stationary phase after its adsorption on sillica gel. Four chiral biphenyl diesters of acidic drugs were resolved. The effect of isopropanol content on resolution has been studied. |
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| Keywords: | HPLC Amylopectin_tris(phenylcarbamate) Racemic acidic drugs Enantiometric resolution |
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