Mechanical ion gate for electrospray-ionization ion-mobility spectrometry |
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Authors: | Li Zhou David C Collins Edgar D Lee Milton L Lee |
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Institution: | (1) Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602-5700, USA;(2) Department of Chemistry, Brigham Young University-Idaho, Rexburg, ID 83460, USA |
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Abstract: | A novel ion gate for electrospray-ionization atmospheric-pressure ion-mobility spectrometry (ESI-IMS) has been constructed
and evaluated. The ion gate consisted of a chopper wheel with two windows—one for periodic ion passage from the ESI source
into the drift region and the other for timing and synchronization purposes. The instrument contained a 45.0 cm long drift
tube comprising 78 stainless steel rings (0.12 cm thick, 4.90 cm o.d., 2.55 cm i.d.). The rings were connected together in
series with 3.34-MΩ resistors. The interface plate and the back plate were also connected with the first and the last rings,
respectively, of the drift tube with 3.34-MΩ resistors. A potential of −20.0 kV was applied to the back plate and the interface
plate was grounded. The drift tube was maintained at an electric field strength of ∼400 V cm−1. An aperture grid was attached to the last ring in front of a Faraday plate detector, center-to-center. Several sample solutions
were electrosprayed at +5.0 kV with +500 V applied to the ion gate. Baseline separations of selected benzodiazepines, antidepressants,
and antibiotics were observed with moderate experimental resolution of ∼70. |
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Keywords: | Ion gate Electrospray ionization Ion-mobility spectrometry Resolution |
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