| 二价金属离子对平阳霉素与DNA作用的影响 |
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| 引用本文： | 王自春 黄登宇. 二价金属离子对平阳霉素与DNA作用的影响[J]. 高等学校化学学报, 1995, 16(3): 410-412 |
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| 作者姓名： | 王自春 黄登宇 |
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| 作者单位： | 山西大学分子科学研究所 |
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| 摘 要： | 二价金属离子对平阳霉素与ＤＮＡ作用的影响王自春，黄登宇，袁静明（山西大学分子科学研究所，太原，０３０００６）关键词二价金属离子，平阳霉素，ＤＮＡ平阳霉素（简称ＢＬＭ－Ａ５）是抗肿瘤抗生素博莱霉素的成分之一，其化学结构、理化性质和药理作用虽基本相同［１...
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| 关 键 词： | 金属离子 平阳霉素 DNA 博莱霉素 |
The Effect of Divalent Metal Inos on the Interaction Between Pingyangmycin and DNA |
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| WANG Zi-Chun,HUANG Deng-Yu,YUAN Jing-Ming. The Effect of Divalent Metal Inos on the Interaction Between Pingyangmycin and DNA[J]. Chemical Research In Chinese Universities, 1995, 16(3): 410-412 |
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| Authors: | WANG Zi-Chun HUANG Deng-Yu YUAN Jing-Ming |
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| Abstract: | Pingyangmycin is an antitumor antibiotics. The therapeutic activity is to degrade template DNA or interfer DNA biosynthesis. It is necessary for the degradation of DNA to have O2 and a metal ion. However,the effect of divalent metal ions on the interaction between Pingyangmycin and DNA is quite different from those of various ions. In this paper, we reported the effect of Fe2+, Co2+, Cu2+, Zn2+ and Mg2+ etc. on DNA clevaged by Pingyangmycin with agarose electrophoresis and CD spectra. The results showed that the degradation of DNA in the presence of Pingyangmycin was obviously increased by Fe2+ or Co2+ and inhibited by Cu2+, Zn2+ or Mg2+. Meanwhile, the possible mechanism of the two kinds of divalent metal ions for the interaction between Pingyangmycin and DNA was also discussed. |
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| Keywords: | Divalent metal ions Pingyangmycin DNA Interaction |
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