Efficient, scalable asymmetric synthesis of an epoxy quinol via Noyori desymmetrization of a meso diketone |
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Authors: | Clay David R Rosenberg Ashley G McIntosh Matthias C |
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Institution: | Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701, USA. |
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Abstract: | Epoxy quinol 1a was prepared on a multi-gram scale by Noyori transfer hydrogenative desymmetrization of the readily available meso epoxy diketone 4. Although the intrinsic enantioselectivity for the desymmetrization was modest (82:18 er at 4% conversion), a highly enantiopure product (99.6:0.4 er) could be obtained in one operation in 44% yield via kinetic resolution of the minor enantiomer with long reaction times (48 h), or in 73% yield by combination with an enzymatic resolution of a 93:7 er mixture. |
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