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Pulse perturbation technique for determination of piroxicam in pharmaceuticals using an oscillatory reaction system |
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| Authors: | Nata?a D. Peji? Nata?a B. Sarap Jelena P. Maksimovi? Slobodan R. Ani? Ljiljana Z. Kolar-Ani? | |
| Affiliation: | 1. Faculty of Pharmacy, Department of Physical Chemistry and the Instrumental Methods, University of Belgrade, 11000, Belgrade, Serbia 2. Institute of Nuclear Science Vin?a, Radiation and Environmental Protection Department, University of Belgrade, 11001, Belgrade, Serbia 3. Faculty of Physical Chemistry, University of Belgrade, 11000, Belgrade, Serbia |
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| Abstract: | A simple and reliable novel kinetic method for the determination of piroxicam (PX) was proposed and validated. For quantitative determination of PX, the Bray-Liebhafsky (BL) oscillatory reaction was used in a stable non-equilibrium stationary state close to the bifurcation point. Under the optimized reaction conditions (T = 55.0°C, [H2SO4]0 = 7.60×10?2 mol L?1, [KIO3]0 = 5.90×10?2 mol L?1, [H2O2]0 = 1.50×10?1 mol L?1 and j 0 = 2.95×10?2 min?1), the linear relationship between maximal potential shift ΔE m , and PX concentration was obtained in the concentration range 11.2–480.5 μg mL?1 with a detection limit of 9.9 μg mL?1. The method had a rather good sample throughput of 25 samples h?1 with a precision RSD = 4.7% as well as recoveries RCV ≤ 104.4%. Applicability of the proposed method to the direct determination of piroxicam in different pharmaceutical formulations (tablets, ampoules and gel) was demonstrated.  | |
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