Complexes of platinum and palladium with 4-nitrobenzoic hydrazide: synthesis and cytotoxic activity |
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| Authors: | Gustavo D de Souza M?nica A Rodrigues Lucianno E Fernandes Priscila P Silva Reinaldo Ruggiero Elene C Pereira-Maia Wendell Guerra |
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| Institution: | 1. Chemistry Institute, Federal University of Uberlandia, Campus Santa M?nica, 38, 400-902, Uberlandia — MG, Brazil
2. Chemistry Department, Federal University of Minas Gerais, Campus Pampulha, 31, 270-901, Belo Horizonte — MG, Brazil
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| Abstract: | New complexes of platinum and palladium were isolated with 4-nitrobenzoic hydrazide (4-NH) and characterized by spectroscopic techniques. Results show that the ligand is coordinated to metallic ions by the basic nitrogen of NH2 group and have the general structure cis-M(4-NH)2X2] where M= Pt or Pd and x = Cl or I. The compound III, Pt(4-NH)2I2], was found to display cytotoxicity (IC50 = 0.96 μmol L?1) against the K562 tumoral cell line. This complex is significantly more cytotoxic than cisplatin.  | |
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