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| 新型铂(Ⅱ)类配合物的合成、表征和抗肿瘤活性 | |
| 引用本文： | 张金超,龚钰秋,郑小明,杨梦甦,崔景荣. 新型铂(Ⅱ)类配合物的合成、表征和抗肿瘤活性[J]. 无机化学学报, 2005, 21(11): 1752-1758 |
| 作者姓名： | 张金超 龚钰秋 郑小明 杨梦甦 崔景荣 |
| 作者单位： | 1. 河北大学化学与环境科学学院,保定,071002 2. 浙江大学化学系,杭州,310028 3. 香港城市大学生物及化学系,香港 4. 北京大学天然药物及仿生药物国家重点实验室,北京,100083 |
| 基金项目： | 浙江省自然科学基金资助项目(No.298068)，北京大学医学部天然药物及仿生药物国家重点实验室资助项目。 |
| 摘 要： | Seven novel platinum(Ⅱ) complexes[Pt(Ⅱ)(NH3)(H2O)X](Ⅰ～Ⅶ) {X=(COO-)2(oxalato), 2p-CH3O-C6H4-COO-(p-methyoxbenzolato), 2C6H5-COO-(benzolato), 2CH3COO-(acetato), (CH2)(COO-)2(malonato), (CH2)2(COO-)2(succinato), (CH=CH)(COO-)2(maleato)} have been prepared and characterized by elemental analysis, thermal analysis，IR, UV, and 1H NMR spectroscopy. The antitumor activities of these complexes in vitro against EJ、HCT-8, KB, BGC-823, Bel-7402, HL-60, MCF-7 and Hela cell lines have been studied. Complex Ⅰ and Ⅴ show remarkable antitumor activities against EJ cell line, and the inhibitory rate is 45.96% and 54.32% at concentration of 10 μmol·L-1, respectively. The inhibitory rate of the complexes Ⅱ and Ⅲ is greater than 50% against HL-60, BGC-823, KB and EJ cell lines. The inhibitory rate of the complex Ⅵ is 51.89% and 57.96% against BGC-823 and EJ cell lines. The complexes Ⅳ and Ⅶ have no antitumor activities against tested tumor cell lines. The complexes Ⅱ, Ⅲ and Ⅵ can stem the cell cycle of HL-60 on the G2+M. |
| 关 键 词： | 铂(Ⅱ)配合物； 抗肿瘤活性； 经典构效关系； 细胞周期 |
| 文章编号： | 1001-4861(2005)11-1752-07 |
| 收稿时间： | 2005-04-18 |
| 修稿时间： | 2005-06-13 |
Synthesis, Characterization and Antitumor Activities of New Type Platinum(II) Complexes |
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| ZHANG Jin-Chao,GONG Yu-Qiu,ZHENG Xiao-Ming,YANG Meng-Su and CUI Jing-Rong. Synthesis, Characterization and Antitumor Activities of New Type Platinum(II) Complexes[J]. Chinese Journal of Inorganic Chemistry, 2005, 21(11): 1752-1758 | |
| Authors: | ZHANG Jin-Chao GONG Yu-Qiu ZHENG Xiao-Ming YANG Meng-Su CUI Jing-Rong |
| Affiliation: | College of Chemistry & Enviromental Science, Hebei University, Baoding 071002,Department of Chemistry, Zhejiang University, Hangzhou 310028,Department of Chemistry, Zhejiang University, Hangzhou 310028,Department of Biology and Chemistry, City University of Hong Kong, Hong Kong and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083 |
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