Reactivity of 3H-1,2,4-dithiazole-3-thiones and 3H-1,2-dithiole-3-thiones as sulfurizing agents for oligonucleotide synthesis |
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Authors: | Andrei P Guzaev |
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Institution: | AM Chemicals LLC, 4065 Oceanside Blvd., Suite M, Oceanside, CA 92056-5824, USA |
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Abstract: | The reactivity of 5-amino-3H-1,2,4-dithiazole-3-thiones substituted at their amino group and 5-amino-3H-1,2-dithiole-3-thiones substituted at their amino group and C4 toward compounds containing P(III) atoms has been studied. N,N-Disubstituted-N′-(3-thioxo-3H-1,2,4-dithiazol-5-yl)methanimidamides were selected as novel efficient sulfur transfer reagents suitable for DNA and RNA synthesis. |
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Keywords: | Oligonucleotide synthesis Phosphorothioate Sulfurization Phosphoramidite synthesis |
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