| Effects of Bases on the Stabilities of Nucleoside C4' Radicals |
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| 作者姓名： | Bo Lin LIN Yao FU Lei LIU Qing Xiang GUO |
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| 作者单位： | Bo Lin LIN，Yao FU，Lei LIU，Qing Xiang GUO Department of Chemistry，University of Science and Technology of China，Hefei 230026 |
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| 基金项目： | 国家自然科学基金，financial support |
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| 摘 要： | C4'-H bond dissociation enthalpies of nucleosides were predicted using theoretical methods to a precision of 1-2 Kcal/mol. It was found that the stability of the C4' nucleoside radical is slightly dependent on the base. The orders of stability are dA < dG < dT < dC for deoxynucleosides and U < G < A = C for nucleosides.
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Effects of Bases on the Stabilities of Nucleoside C4' Radicals |
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| Bo Lin LIN,Yao FU,Lei LIU,Qing Xiang GUO.Effects of Bases on the Stabilities of Nucleoside C4'''' Radicals[J].Chinese Chemical Letters,2003,14(10). |
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| Authors: | Bo Lin LIN Yao FU Lei LIU Qing Xiang GUO |
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| Abstract: | C4'-H bond dissociation enthalpies of nucleosides were predicted using theoretical methods to a precision of 1-2 Kcal/mol. It was found that the stability of the C4' nucleoside radical is slightly dependent on the base. The orders of stability are dA < dG < dT < dC for deoxynucleosides and U < G < A = C for nucleosides. |
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| Keywords: | Nucleoside homolysis bond energy DNA lesion substituent effect |
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