Lewis acid promoted aldol additions of α-thiosilylketeneacetals to α-alkoxy aldehydes: diastereoselective synthesis of
-α-methylene-β-hydroxy-∂-alkoxy esters. |
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| Authors: | Anna Bernardi Silvia Cardani Cesare Gennari Giovanni Poli Carlo Scolastico |
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| Institution: | Anna Bernardi, Silvia Cardani, Cesare Gennari, Giovanni Poli,Carlo Scolastico, * |
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| Abstract: | MgBr2 mediated addition of Methyl α-methylthio propionate silylketene acetal to α and α,β-alkoxy aldehydes is highly 3,4
-selective (18:1).
-α- methylene-β- hydroxy-∂-alkoxy esters (6) and (8) are synthesized. |
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