| Fe65L2基因存在4种剪接形式 |
| |
| 引用本文： | 孙朝辉,陈宣茂,林盛榕,应康,谢毅,毛裕民.Fe65L2基因存在4种剪接形式[J].复旦学报(自然科学版),2000,39(2):231-234. |
| |
| 作者姓名： | 孙朝辉 陈宣茂 林盛榕 应康 谢毅 毛裕民 |
| |
| 作者单位： | 上海复旦大学生命科学学院遗传学研究所 |
| |
| 基金项目： | 国家科委新药研究与产业化开发项目!（96－901－01－58），上海市现代生物与新药产业发展基金!（984319121） |
| |
| 摘 要： | Ｆｅ６５Ｌ２是一种与老年痴呆症关蛋白－淀粉样肽前体蛋白相互作用的蛋白。报道了Ｆｅ６５Ｌ２基因的２种新的剪接形式，并证实了该基因存在４种剪接形式。这４种剪接形式是由同一个内含子中分别为６ｎｔ和２１ｎｔ的２段外显子序列按不同组合拼接而成的。
|
| 关 键 词： | 老年痴呆症 Fe65L2基因 剪接形式 APP 可变剪接 |
| 文章编号： | 0427-7104(2000)02-0231-04 |
The Alternative Splicing of Fe65L2 Gene Generates 4 Isoforms |
| |
| SUN Zhao-hui,CHEN Xuan-mao,LIN Sheng-rong,YING Kang,XIE Yi,MAC Yu-min.The Alternative Splicing of Fe65L2 Gene Generates 4 Isoforms[J].Journal of Fudan University(Natural Science),2000,39(2):231-234. |
| |
| Authors: | SUN Zhao-hui CHEN Xuan-mao LIN Sheng-rong YING Kang XIE Yi MAC Yu-min |
| |
| Institution: | SUN Zhao-hui
,CHEN Xuan-mao
,LIN Sheng-rong
,YING Kang
,XIE Yi
,MAC Yu-min
(Instiute of Genetics,School of Life Science) |
| |
| Abstract: | Fe65L2 is a protein which interacts with Amyloid Precursor Protein (APP), the Alzheimer's Diseaserelated protein. Two novel splice variants of Fe65L2 gene were reported in this study, confirming that the alternative splicing of this gene generated at least 4 isoforms. These 4 splicing variants resulted from 4 recombina nons of 2 miniexons within a single intron whose length are 6 nt and 21 nt respectively. |
| |
| Keywords: | Alzheimer's Disease (AD) Fe65L2 gene Amyloid Precursur Protein(APP) PID1 PID2 WW do main alternative splicing |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
