(-)-Lytophilippine A: synthesis of a C1-C18 building block |
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Authors: | Gille Annika Hiersemann Martin |
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Institution: | Fakulta?t Chemie, Technische Universita?t Dortmund, 44227 Dortmund, Germany. annika.gille@tu-dortmund.de |
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Abstract: | The convergent enantioselective synthesis of a protected C1-C18 building block for the total synthesis of (-)-lytophilippine A was achieved. A catalytic asymmetric Gosteli-Claisen rearrangement and an Evans aldol reaction served as key C/C-connecting transformations during the assembling of the C1-C7 subunit (10 steps from 4, 29%). The synthesis of the C8-C18 segment was achieved utilizing d-galactose as inexpensive ex-chiral-pool starting material (15 steps, 15%). The merger of the subunits was accomplished by a remarkably efficient sequence consisting of esterification and ring-closing metathesis (five steps, 56%). |
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