Studies on the Interactions Between Genistein and Copolymer F127

In this paper, the interactions of an isoflavone molecule, Genistein (Gen), with Pluronic F127 at different pH values have been investigated using laser light scattering techniques, film analysis methods, UV-vis spectroscopy and transmission electron microscopy. The TEM images and the DSL studies indicate the formation of a Gen/F127 complex induced by the solubilization of Gen in micelles, and the stability of the Gen/F127 complex decreases with the increase of pH. At pH of 6.4, the turbidity of the Gen/F127 complex solution is significantly reduced in the presence of 0.31 mol⋅L⁻¹ ethylene glycol, indicating the existence of hydrogen bonds between Gen and the F127 copolymer. Experiments on controlled release demonstrate that Gen-loaded F127 micelles act as a drug carrier, giving slow release to the surrounding solution over a period of time. Rapid release can be triggered by increasing the pH of the micelle solutions