[1]College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, P R. China [2]Genetic Engineering Laboratory, Academy of Military Medical Sciences, Changchun 130062, P. R. China
Abstract:
Designing adjuvants that can induce strong cytotoxic T cell responses is largely required for preparing DNA vaccines. In this study we explored dual costimulatory molecules 4-1BBL and OX40L as adjuvants to improve the efficiency of the HIV multiple-epitope DNA vaccine. When explored in the human dendritic cell-T cell based coculture system,dual costimulatory molecules significantly enhanced the anti-HIV T cell response of the HIV mul-tiple-epitope DNA vaccine,as detected by intracellular cytokine staining t...