Self-assembled multivalency: dynamic ligand arrays for high-affinity binding |
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Authors: | Barnard Anna Smith David K |
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Institution: | Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK. |
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Abstract: | Multivalency is a powerful strategy for achieving high-affinity molecular recognition in biological systems. Recently, attention has begun to focus on using self-assembly rather than covalent scaffold synthesis to organize multiple ligands. This approach has a number of advantages, including ease of synthesis/assembly, tunability of nanostructure morphology and ligands, potential to incorporate multiple active units, and the responsive nature of self-assembly. We suggest that self-assembled multivalency is a strategy of fundamental importance in the design of synthetic nanosystems to intervene in biological pathways and has potential applications in nanomedicine. |
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Keywords: | molecular recognition multivalency non‐covalent interactions self‐assembly supramolecular chemistry |
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