乙酸促进邻甲基苯磺酸铜选择性催化醛与乙酸酐合成偕二乙酸酯反应

在室温无溶剂条件下,考察了乙酸促进邻甲基苯磺酸铜催化一系列芳香醛或脂肪醛与乙酸酐生成相应的偕二乙酸酯反应.结果表明,在乙酸存在条件下,邻甲基苯磺酸铜用量仅需占醛的0.3%(摩尔比)就能使反应在较短时间内完成.反应结束后,邻甲基苯磺酸铜经简单相分离可多次重复使用,催化活性无明显下降.

Selective Synthesis of Gem-Diacetates from Aldehydes and Acetic Anhydride Catalyzed by Acetic Acid-Assisted Copper o-Toluenesulfonate

Gem-diacetates were synthesized from corresponding aromatic or aliphatic aldehydes and acetic anhydride catalysed by acetic acid-assisted copper o-toluenesulfonate as synergistic catalysts at room temperature under solvent-free conditions. The catalytic activity of acetic acid-assisted copper o-toluenesulfonate was much higher than that without acetic acid under the same conditions. Only a molar ratio of 0.3% of copper o-toluenesulfonate to aldehyde was needed to complete the reaction in short time. After reaction, the copper o-toluenesulfonate could be easily recovered by phase separation and could be reused five times without distinct decrease in its catalytic activity.