|
|||||
|
|
Manganese(I)‐Catalyzed C−H Activation: The Key Role of a 7‐Membered Manganacycle in H‐Transfer and Reductive Elimination |
|
| Authors: | Dr Nasiru P Yahaya Kate M Appleby Magdalene Teh Conrad Wagner Erik Troschke Joshua T W Bray Prof Simon B Duckett L Anders Hammarback Dr Jonathan S Ward Jessica Milani Dr Natalie E Pridmore Dr Adrian C Whitwood Dr Jason M Lynam Prof Ian J S Fairlamb |
| Institution: | Department of Chemistry, University of York, York, UK |
| Abstract: | Manganese‐catalyzed C?H bond activation chemistry is emerging as a powerful and complementary method for molecular functionalization. A highly reactive seven‐membered MnI intermediate is detected and characterized that is effective for H‐transfer or reductive elimination to deliver alkenylated or pyridinium products, respectively. The two pathways are determined at MnI by judicious choice of an electron‐deficient 2‐pyrone substrate containing a 2‐pyridyl directing group, which undergoes regioselective C?H bond activation, serving as a valuable system for probing the mechanistic features of Mn C?H bond activation chemistry. |
| Keywords: | catalysis C− H activation functionalization manganese sustainability |