Use of an Octapeptide–Guanidiniocarbonylpyrrole Conjugate for the Formation of a Supramolecular β‐Helix that Self‐Assembles into pH‐Responsive Fibers |
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Authors: | Mao Li Marijana Radi??Stojkovi? Martin Ehlers Elio Zellermann Prof Ivo Piantanida Prof Carsten Schmuck |
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Institution: | 1. Institute for Organic Chemistry, University of Duisburg-Essen, Essen, Germany;2. Division of Organic Chemistry and Biochemistry, Ru?er Bo?kovi? Institute, Zagreb, Croatia |
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Abstract: | Peptides that adopt β‐helix structures are predominantly found in transmembrane protein domains or in the lipid bilayer of vesicles. Constructing a β‐helix structure in pure water has been considered difficult without the addition of membrane mimics. Herein, we report such an example; peptide 1 self‐assembles into a supramolecular β‐helix in pure water based on charge interactions between the individual peptides. Peptide 1 further showed intriguing transitions from small particles to helical fibers in a time‐dependent process. The fibers can be switched to vesicles by changing the pH value. |
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Keywords: | ion pair formation molecular recognition peptide fibers peptide structures self-assembly |
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