Activation of Platinum(IV) Prodrugs By Motexafin Gadolinium as a Redox Mediator |
| |
| Authors: | Dr. Gregory Thiabaud Rebecca McCall Dr. Guangan He Prof. Jonathan F. Arambula Prof. Zahid H. Siddik Prof. Jonathan L. Sessler |
| |
| Affiliation: | 1. Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, TX, USA;2. Department of Chemistry, Georgia Southern University, Statesboro, GA, USA;3. The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA |
| |
| Abstract: | Water‐soluble platinum(IV) prodrugs, which proved kinetically stable to reduction in the presence of physiological concentration of ascorbate, were quickly reduced to their active form, oxaliplatin, when co‐incubated with a macrocycle metallotexaphyrin (i.e., Motexafin Gadolinium (MGd)). The reduction of PtIV to PtII promoted by MGd occurs in cell culture as well, leading to an increase in the antiproliferative activity of the PtIV species in question. The mediated effect is proportional to the concentration of MGd and gives rise to an enhancement when the prodrug is relatively hydrophilic. MGd is known to localize/accumulate preferentially in tumor tissues. Thus, the present “activation by reduction” approach may allow for the cancer‐selective enhancement in the cytotoxicity of PtIV prodrugs. |
| |
| Keywords: | antitumor agents metallotexaphyrin platinum prodrugs redox chemistry |
|
|
