A Synthetic Supramolecular Receptor for the Hydrosulfide Anion |
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| Authors: | Matthew D Hartle Ryan J Hansen Dr Blakely W Tresca Samuel S Prakel Lev N Zakharov Prof Michael M Haley Prof Michael D Pluth Prof Darren W Johnson |
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| Institution: | 1. Department of Chemistry & Biochemistry, Materials Science Institute, and Institute of Molecular Biology, University of Oregon, Eugene, OR, USA;2. CAMCOR—Center for Advanced Materials Characterization in Oregon, University of Oregon, Eugene, OR, USA |
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| Abstract: | Hydrogen sulfide (H2S) has emerged as a crucial biomolecule in physiology and cellular signaling. Key challenges associated with developing new chemical tools for understanding the biological roles of H2S include developing platforms that enable reversible binding of this important biomolecule. The first synthetic small molecule receptor for the hydrosulfide anion, HS?, using only reversible, hydrogen‐bonding interactions in a series of bis(ethynylaniline) derivatives, is reported. Binding constants of up to 90 300±8700 m ?1 were obtained in MeCN. The fundamental science of reversible sulfide binding, in this case featuring a key CH???S hydrogen bond, will expand the possibility for discovery of sulfide protein targets and molecular recognition agents. |
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| Keywords: | anion binding gasotransmitters molecular recognition sulfide supramolecular chemistry |
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