Mixed Aggregates of the Dilithiated Koga Tetraamine: NMR Spectroscopic and Computational Studies |
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| Authors: | Dr. Yun Ma Kyle A. Mack Dr. Jun Liang Dr. Ivan Keresztes Prof. David B. Collum Prof. Armen Zakarian |
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| Affiliation: | 1. Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA;2. Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, USA |
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| Abstract: | A combination of 1H, 6Li, 13C, and 15N NMR spectroscopies and density functional theory computations explores the formation of mixed aggregates by a dilithium salt of a C2‐symmetric chiral tetraamine (Koga's base). Lithium halides, acetylides, alkoxides, and monoalkylamides form isostructural trilithiated mixed aggregates with few exceptions. 6Li–13C and 6Li–15N couplings reveal heretofore undetected transannular contacts (laddering) with lithium acetylides and lithium monoalkylamides. Marked temperature‐dependent 15N chemical shifts seem to be associated with this laddering. Computational studies shed light on the general structures of the aggregates, their penchant for laddering, and the stereochemical consequences of aggregation. |
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| Keywords: | aggregation enantioselectivity lithium NMR spectroscopy synthetic methods |
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