Template‐Directed Synthesis of Porous and Protective Core–Shell Bionanoparticles |
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Authors: | Shaobo Li Madushani Dharmarwardana Raymond P. Welch Yixin Ren Dr. Christina M. Thompson Prof. Ronald A. Smaldone Prof. Jeremiah J. Gassensmith |
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Affiliation: | 1. http://gassensmithlab.com;2. Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX, USA |
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Abstract: | Metal–organic frameworks (MOFs) are promising high surface area coordination polymers with tunable pore structures and functionality; however, a lack of good size and morphological control over the as‐prepared MOFs has persisted as an issue in their application. Herein, we show how a robust protein template, tobacco mosaic virus (TMV), can be used to regulate the size and shape of as‐fabricated MOF materials. We were able to obtain discrete rod‐shaped TMV@MOF core–shell hybrids with good uniformity, and their diameters could be tuned by adjusting the synthetic conditions, which can also significantly impact the stability of the core–shell composite. More interestingly, the virus particle underneath the MOF shell can be chemically modified using a standard bioconjugation reaction, showing mass transportation within the MOF shell. |
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Keywords: | bioconjugation reactions metal– organic frameworks nanoparticles tobacco mosaic virus |
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