Nickel‐Catalyzed Methylation of Aryl Halides with Deuterated Methyl Iodide |
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| Authors: | Lu Hu Xin Liu Prof Xuebin Liao |
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| Institution: | Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Tsinghua University, Beijing, China |
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| Abstract: | A nickel‐catalyzed methylation of aryl halides with cheap and readily available CH3I or CD3I is described. The reaction is applicable to a wide range of substrates and allows installation of a CD3 group under mild reaction conditions without deuterium scrambling to other carbon atoms. Initial mechanistic studies on the stoichiometric and catalytic reactions of the isolated (dppp)Ni(C6H4‐4‐CO2Et)Br] dppp=1,3‐bis(diphenylphosphanyl)propane] suggest that a Ni0/NiII catalytic cycle is favored. |
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| Keywords: | arenes cross-coupling deuterium methylation nickel |
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