Diastereoselective Synthesis of Cyclopenta[c]furans by a Catalytic Multicomponent Reaction |
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| Authors: | Stalin R. Pathipati Angela van der Werf Prof. Lars Eriksson Dr. Nicklas Selander |
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| Affiliation: | 1. Department of Organic Chemistry, Stockholm University, Arrhenius Laboratory, Stockholm, Sweden;2. Department of Materials and Environmental Chemistry, Stockholm University, Arrhenius Laboratory, Stockholm, Sweden |
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| Abstract: | A diastereoselective three‐component reaction between alkynyl enones, aldehydes and secondary amines is reported. With the aid of a benign indium catalyst, a range of highly substituted cyclopenta[c]furan derivatives can be obtained in a single‐step procedure. The formation of the stereodefined heterocyclic motifs takes place via in situ generation of enamines followed by two sequential cyclization steps. |
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| Keywords: | alkynes enones fused-ring systems indium catalysis multicomponent reactions |
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