A Copper‐Catalyzed Decarboxylative Amination/Hydroamination Sequence: Switchable Synthesis of Functionalized Indoles |
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| Authors: | Tian‐Ren Li Bei‐Yi Cheng Ya‐Ni Wang Mao‐Mao Zhang Prof Dr Liang‐Qiu Lu Prof Dr Wen‐Jing Xiao |
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| Institution: | 1. Key Laboratory of Pesticide & Chemical Biology Ministry of Education, College of Chemistry, Central China Normal University, Hubei, China;2. Collaborative Innovation Center of Chemical Science and Engineering, Tianjin), China |
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| Abstract: | A copper‐catalyzed decarboxylative amination/hydroamination sequence of propargylic carbamates with various nucleophiles is described for the first time. It features an earth‐abundant metal catalyst, mild reaction conditions, and high efficiency. Further treatments of the resultant key intermediates using an acid or a base in one pot enable the controllable and divergent synthesis of two types of functionalized indoles. Moreover, experiments to demonstrate the synthetic potential of this methodology are performed. |
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| Keywords: | alkynes copper hydroamination indoles synthetic methods |
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