Molecular origin for the thermal stability of schizophyllan |
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| Institution: | 1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China;2. Jilin Agricultural University, Changchun 130118, China;3. Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medicinal Sciences & Peking Union Medical College, Wanning 571533, China;1. Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand;2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand;1. Department of Chemistry, Ferdowsi University of Mashhad, Mashhad, Iran;2. Microbial Biotechnology Department, Semnan University, Semnan, Iran;3. Manufacturing and Industrial Engineering Department, The University of Texas Rio Grande Valley, Edinburg, TX, United States;4. Department of Biological Sciences, California State Polytechnic University, Pomona, CA, United States;1. School of Food and Biological Engineering, Jiangsu University, No. 301 Xuefu Road, Zhenjiang 212013, China;2. Jiangsu Provincial Key Laboratory for Physical Processing of Agricultural Products, Jiangsu University, No. 301 Xuefu Road, Zhenjiang 212013, China;3. Jiangsu Provincial Research Center of Bio-process and Separation Engineering of Agri-products, Jiangsu University, No. 301 Xuefu Road, Zhenjiang 212013, China;4. Zhejiang Provincial Top Key Discipline of Biological Engineering, No. 8 South Qian Hu Road, Ningbo 315100, China;5. College of Biological and Environmental Sciences, Zhejiang Wanli University, No. 8 South Qian Hu Road, Ningbo 315100, China;1. Faculty of Pharmacy, Siam University, Bangkok, 10160, Thailand;2. Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand;3. Pharmaceutical Biopolymer Group (PBiG), Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand;4. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand |
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| Abstract: | The non-Newtonian behavior, dynamic viscoelasticity and optical rotation of schizophyllan solutions were measured with a rheogoniometer and polarimeter. Schizophyllan showed shear-thinning behavior below 0.3%, but plastic behavior above 0.5%. Gelation occurred for native and sonic degraded schizophyllan at concentrations of 0.8 and 2.0% at 0 °C, but melted when the temperature reached 5 °C, which was estimated to be a transition temperature. However, the dynamic modulus stayed at a large value during an increase in temperature up to 85 °C. A small decrease in the dynamic modulus of schizophyllan was observed upon addition of urea (4.0 M). A transition temperature was observed when the temperature of schizophyllan reached 60 ° in 0.1 N NaOH and in 85% dimethyl sulfoxide solution, respectively. Though the optical rotation remained constant during a decrease in temperature up to 15 °C, it increased with further decrease in temperature.The thermostability of the dynamic viscoelasticity of schizophyllan may be essentially attributed to an intramolecular hydrogen bonding in aqueous solution. A possible mode of an intramolecular hydrogen bonding for schizophyllan was proposed. |
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