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| Palladium-catalyzed asymmetric allylic C–H alkylation of 1,4-dienes and glycine Schiff bases | |
| 摘 要： | A highly regio-and enantioselective allylic C–H alkylation of 1,4-dienes with glycine Schiff bases has been established by chiral palladium-phosphoramidite catalysis. This reaction can proceed under mild conditions and tolerate a wide scope of 1,4-dienes,delivering structurally diverse chiral β-branched α-amino acid surrogates in moderate to high yields and with high levels of regio-, Z/E-, diastereo-and enantioselectivities. |
Palladium-catalyzed asymmetric allylic C-H alkylation of 1,4-dienes and glycine Schiff bases |
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| Authors: | Wang Tian-Ci Wang Pu-Sheng Gong Liu-Zhu |
| Institution: | 1.Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China ;2.Center for Excellence in Molecular Synthesis of Chinese Academy of Sciences, Hefei, 230026, China ; |
| Abstract: | Science China Chemistry - A highly regio- and enantioselective allylic C-H alkylation of 1,4-dienes with glycine Schiff bases has been established by chiral palladium-phosphoramidite catalysis.... |
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