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| NIR-Ⅱ probe modified by poly(L-lysine) with efficient ovalbumin delivery for dendritic cell tracking | |
| 摘 要： | |
NIR-II probe modified by poly(L-lysine) with efficient ovalbumin delivery for dendritic cell tracking |
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| Authors: | Wang Chao Sun Bo Bao Hui Wang Tao Xu Wenjuan Sun Pengfei Fan Quli Huang Wei |
| Institution: | 1.Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing University of Posts & Telecommunications, Nanjing, 210023, China ;2.Frontiers Science Center for Flexible Electronics & Shaanxi Institute of Flexible Electronics, Northwestern Polytechnical University, Xi’an, 710072, China ; |
| Abstract: | Dendritic cell(DC) vaccine is an effective strategy for cancer immunotherapy by carrying antigen into DCs and migrating these DCs to drain lymph nodes after inoculation. In this article, second near-infrared window(NIR-II) fluorescent nanoparticles have been used to uptake antigen and activate DCs. Ovalbumin(OVA), an antigen for immunization, can be loaded on the surface of these NIR-II fluorescent nanoparticles via electrostatic interaction by virtue of their functionalized poly(L-lysine)(PLL), which exhibits biocompatibility and strong selective interaction with OVA. In addition, these antigen-loaded complexes can efficiently be engulfed by immature DCs to induce DC maturation and cytokine secretion. After subcutaneous injection, highly sensitive NIR-II fluorescence signal from nanoparticles indicates that nanoparticle-labeled DCs can successfully migrate into lymph nodes in vivo, showing great promise in immunotherapy against cancer. |
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| 本文献已被 CNKI SpringerLink 等数据库收录！ | |