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Aggregation-induced emission luminogen for specific identification of malignant tumour in vivo |
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| Authors: | Shen Jianlei Tao Kun Gu Peilin Gui Chen Wang Dong Tan Zhenyu Wang Lihua Wang Zhiming Qin Anjun Tang Ben Zhong Bao Shisan |
| Institution: | 1.School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China ;2.Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China ;3.Discipline of Pathology, Bosch Institute and School of Medical Sciences, Charles Perkins Centre, The University of Sydney, Sydney, Australia ;4.Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China ;5.Department of Chemistry, HKUST Jockey Club Institute for Advanced Study, Institute of Molecular Functional Materials, Division of Biomedical Engineering, State Key Laboratory of Molecular Neuroscience, Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China ;6.State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, 510640, China ; |
| Abstract: | Colorectal cancer(CRC) is still a major killer,mainly due to the lack of early detection biomarker with sensitivity/specificity.Conventional histopathology is the gold standard approach in practice,but there are still some issues(false diagnosis and long waiting period).Aggregation-induced emission(AIE) is a novel photophysical phenomenon which has been widely utilized for biological imaging in vitro,including malignant cells,showing remarkable imaging contrast and enhanced emission in high concentrated state.However,it is unclear if AIE dyes can identify malignant cells specifically in vivo.A great challenge for specific labeling of malignant cells is probably ascribed to the complex compositions in tumor tissues.Herein,an AIE dye-based mitochondria-targeted histological staining strategy was employed to localize cancer and the metastatic track in the fresh colorectal cancer.This novel approach holds great potential to revolutionize the clinical diagnosis and intervention for devastating malignancy. |
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