| Transformations of N-arylpropiolamides to indoline-2,3-diones and acids via C≡C triple bond oxidative cleavage and C(sp^2)–H functionalization |
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| 作者姓名： | Ming-Bo Zhou Yang Li Xuan-Hui Ouyang Jin-Heng Li |
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| 作者单位： | Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle;Key Laboratory of Chemical Biology&Traditional Chinese Medicine Research（Ministry of Education）;State Key Laboratory of Applied Organic Chemistry |
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| 基金项目： | supported by the National Natural Science Foundation of China(21625203,21871126);the Opening Fund of KLCBTCMR,Ministry of Education(KLCBTCMR18-02) |
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| 摘 要： | A new palladium-catalyzed oxidative conversion of N-arylpropiolamides and H2O to various indoline-2,3-diones and acids through the C≡C triple bond cleavage and C(sp2)–H functionalization is described,which is promoted by a cooperative action of catalytic CuBr2,2,2,6,6-tetramethyl-1-piperidinyloxy(TEMPO)and O2.The method provides a practical tool for transformations of alkynes by means of a C–H functionalization strategy,which enables the formation of one C–C bond and multiple C–O bonds in a single reaction with high substrates compatibility and excellent functional group tolerance.
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| 关 键 词： | ALKYNES indoline-2 3-diones ACIDS C≡C bond oxidative cleavage C–H functionalization |
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