Solid-phase synthesis of cyclic PNA and PNA-DNA chimeras |
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Authors: | Moggio Loredana De Napoli Lorenzo Di Blasio Benedetto Di Fabio Giovanni D'Onofrio Jennifer Montesarchio Daniela Messere Anna |
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Institution: | Dipartimento di Scienze Ambientali, Seconda Università di Napoli, Caserta, Italy. |
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Abstract: | structure: see text] A new and versatile on-line automated solid-phase approach to obtain cyclic PNA (I and III) and cyclic PNA-DNA chimeras (II) in highly pure form has been developed. Starting from a Tentagel matrix functionalized with a 3-chloro-4-hydroxyphenylacetic linker, the synthesis of representative, new cyclic molecules by standard peptide and phosphoramidite-based chemistry has been achieved. |
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