新型白藜芦醇类衍生物的合成研究

以没食子酸为原料, 通过甲基化、还原、溴代、Arbuzov重排、Wittig-Horner反应、O - 异戊烯基或O - 法尼烯基化等反应步骤,以总收率30%～35%合成了6种未见文献报道的新型的白藜芦醇类衍生物1a,1b,2a～2d. 所合成的化合物已通过MS,1HNMR和IR等波谱方法进行了结构确证. 该合成方法具有反应条件温和、后处理方便、产率较高和立体选择性强的优点.

Studies on the Synthesis of New Resveratrol Derivatives

Six new resveratrol derivatives 1a,1b,2a～2d, were synthesized in reaction steps including methylation, reducation, bromization, Arbuzov rearrangement , Wittig-Horner reaction, O-perenylation and O-farnesylation respectively using gallic acid as the starting material in overall yields of 30%～35%. Their structures were confirmed with MS,1HNMR and IR spectra. This synthetic method has the advantages of mild reaction condition, simple operation, high stereospecificticg and good yields, so it has considerable practical value.