A novel reagent combination for the oxidation of highly electron deficient pyridines to N-oxides: trifluoromethanesulfonic anhydride/sodium percarbonate |
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| Authors: | Xizhen Zhu Kevin D Kreutter Huaping Hu Mark R Player Micheal D Gaul |
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| Institution: | Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 8 Clarke Drive, Cranbury, NJ 08512, USA |
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| Abstract: | A novel reagent combination, Tf2O/Na2CO3·1.5H2O2, has been developed for the oxidation of highly electron deficient pyridines to their corresponding N-oxides. The N-oxidation reaction, utilizing the in situ generated peracid, proceeds under mild conditions that allow for a number of functional groups and substitution patterns on the pyridine ring. |
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| Keywords: | Pyridine Pyridine N-oxide Trifluoromethanesulfonic anhydride Sodium percarbonate |
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