Synthesis of the C1-C12 fragment of the tedanolides. Selective hydroboration-protonation of allylic alcohol approach |
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Authors: | Michael E Jung Dongwon Yoo |
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Institution: | Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095-1569, United States |
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Abstract: | The combination of highly stereoselective vinyllithium addition and hydroboration-protonation of the resulting allylic alcohol permits the preparation of the completely protected C1-C12 fragment 2 of the novel macrocyclic cytotoxic agent tedanolide 1. |
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