| 新型酸性离子液体催化的 Knoevenagel缩合反应 |
| |
| 引用本文： | 泮丽亚,李志峰,倪宇翔,姚振刚,余志平,吴文康,应安国. 新型酸性离子液体催化的 Knoevenagel缩合反应[J]. 高等学校化学学报, 2015, 36(1): 81-86. DOI: 10.7503/cjcu20140685 |
| |
| 作者姓名： | 泮丽亚 李志峰 倪宇翔 姚振刚 余志平 吴文康 应安国 |
| |
| 作者单位： | 1. 台州学院医药化工学院, 台州 318000;2. 天津大学化工学院, 天津 300072;3. 浙江省低碳脂肪胺工程技术研究中心, 杭州 311604 |
| |
| 基金项目： | 国家自然科学基金(批准号:21106090)、国家级大学生创新训练项目(批准号:201410350018)和浙江省低碳脂肪胺工程技术研究中心开放基金项目(批准号:2012E10033)资助. |
| |
| 摘 要： | 研究了一类新型酸性离子液体催化的Knoevenagel缩合反应, 结果表明, 该催化剂适用于一系列芳香/杂环醛与α-取代活性亚甲基化合物间的反应, 反应可在室温下进行, 反应时间短且收率良好(92% ~98%). 该反应体系操作简单, 产物易分离. 提出了可能的反应机理并对机理进行了验证. 该离子液体重复使用5次后仍具有较高的反应活性.
|
| 关 键 词： | 新型酸性离子液体 Knoevenagel缩合反应 绿色化学 重复使用性 |
| 收稿时间： | 2014-07-24 |
Knoevenagel Condensation Catalyzed by Novel Acidic Ionic Liquid |
| |
| PAN Liya,LI Zhifeng,NI Yuxiang,YAO Zhengang,YU Zhiping,WU Wenkang,YING Anguo. Knoevenagel Condensation Catalyzed by Novel Acidic Ionic Liquid[J]. Chemical Research In Chinese Universities, 2015, 36(1): 81-86. DOI: 10.7503/cjcu20140685 |
| |
| Authors: | PAN Liya LI Zhifeng NI Yuxiang YAO Zhengang YU Zhiping WU Wenkang YING Anguo |
| |
| Affiliation: | 1. School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou 318000, China;2. School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;3. Low Carbon Fatty Amine Engineering Research Center of Zhejiang Province, Hangzhou 311604, China |
| |
| Abstract: | A series of novel multiacidic ionic liquids([TEOA] [CF3COO]) based on triethanolamine were synthesized through the two-step method and introduced as catalysts for Knoevenagel condensation of complex active methylene compounds. [TEOA] [CF3COO] showed the best catalytic performance. The reactions were carried out at room temperature and the amount of catalyst was only 2%(molar fraction). The reaction system was applicable to a wide range of aromatic/heteroaromatic aldehydes with the complex α-substituted active methylene compounds affording the products in excellent yields(92%—98%) within minutes. The reaction system was operationally simple and the desired products could be easily separated from the reaction mixture. A plausible mechanism for the Knoevenagel reaction catalyzed by [TEOA] [CF3COO] was proposed and the relevant evidences were given. In addition, the ionic liquid could be regenerated and recycled five timeswithout a significant loss of activity. |
| |
| Keywords: | Novel acidic ionic liquid Knoevenagel condensation Green chemistry Recyclability |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《高等学校化学学报》浏览原始摘要信息 |
|
点击此处可从《高等学校化学学报》下载全文 |
|
