Synthesis,characterization and cytotoxic activity of novel Cu(II) and Co(II) complexes with 3-amino-5,5-dimethylhydantoin |
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| Institution: | 1. Department of Analytical Chemistry, University of Chemical Technology and Metallurgy, Sofia 1756, Bulgaria;2. Department of Organic Chemistry, University of Chemical Technology and Metallurgy, Sofia 1756, Bulgaria;3. Institute of Experimental Morphology, Pathology and Anthropology with Muzeum, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Bl. 25, Sofia 1113, Bulgaria |
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| Abstract: | Novel mixed complexes of copper (II) and cobalt (II) with 3-amino-5,5-dimethylhydantoin were synthesized and their in vitro anticancer activity was investigated. The structures of the compounds were confirmed by IR, UV–Vis spectrometry, voltammetry and elemental analysis. The cytotoxic effects of novel complexes of copper (II) and cobalt (II) with 3-amino-5,5-dimethylhydantoin were tested against a panel of human tumor cell lines. All of the compounds investigated exhibited different concentration-dependent antiproliferative effects against the HT29, MDA-MB-231, HepG2 and HeLa cell lines after 24 h of treatment. The most sensitive cells were the HepG2 cells at various concentrations of both tested compounds followed by HT29. |
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| Keywords: | Copper and cobalt complexes 5 5-Disubstituted hydantoins Cytotoxic activity Human tumor cell lines Voltammetry |
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