Electrocatalytic multicomponent assembling of phthalhydrazide,aldehydes and malononitrile: An efficient approach to 1H-pyrazolo[1,2-b]phthalazine-5,10-diones |
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Institution: | 1. Department of Chemistry, Guilan Science and Research Branch, Islamic Azad University, Rasht, Iran;2. Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Iran;3. Young Researchers and Elite Club, Guilan Science and Research Branch, Islamic Azad University, Rasht, Iran |
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Abstract: | Electrocatalytic multicomponent transformation of phthalhydrazide, aromatic aldehydes and malononitrile in n-propanol in an undivided cell in the presence of sodium bromide as an electrolyte leads to 1H-pyrazolo1,2-b]phthalazine-5,10-diones in short reaction times (4–8 min) and high yields (85–98%) at room temperature. The developed efficient electrocatalytic approach to the corresponding 1H-pyrazolo1,2-b]phthalazine-5,10-diones is beneficial from the viewpoint of diversity-oriented large-scale processes and represents a new example of the ecologically pure synthetic concept for electrocatalytic multicomponent reactions strategy. |
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Keywords: | Electrocatalytic transformation Electrogenerated base Phthalhydrazide Multicomponent reaction |
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