p-Toluenesulfonic acid-catalyzed one-pot synthesis of 2-amino-4-substituted-1,4-dihydrobenzo[4,5]imidazolo[1,2-a]pyrimidine-3-carbonitriles under neat conditions |
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Institution: | Department of Image Science and Engineering, Pukyong National University, Busan 608-737, Korea |
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Abstract: | A simple, efficient, and green procedure for the preparation of 2-amino-4-substituted-1,4-dihydrobenzolo4,5]imidazolo1,2-a]pyrimidine-3-carbonitriles has been developed by multi-component condensation of 2-aminobenzimidazole with aldehydes and malononitrile in the presence of a catalytic amount of p-toluenesulfonic acid, affording excellent yields under neat conditions. The protocol avoids the use of expensive catalysts, toxic solvents, and chromatographic separation. We believe that this new environmentally metal-free procedure, combined to a solvent-free reaction, would be of importance in the search of green laboratory-scale synthesis. |
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Keywords: | 1 4-Dihydrobenzo[4 5]imidazolo[1 2-a]pyrimidines Solvent-free reaction 2-Aminobenzimidazole Malononitrile |
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