| 中药色谱指纹图谱相似度计算中保留时间校正方法的研究 |
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| 引用本文： | 柴逸峰,罗国安,乔善磊,朱臻宇,陆峰,王建军. 中药色谱指纹图谱相似度计算中保留时间校正方法的研究[J]. 分析化学, 2005, 33(11): 1599-1602 |
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| 作者姓名： | 柴逸峰 罗国安 乔善磊 朱臻宇 陆峰 王建军 |
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| 作者单位： | 第二军医大学药学院,上海,200433;清华大学化学系,北京,100084;清华大学化学系,北京,100084;第二军医大学药学院,上海,200433 |
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| 摘 要： | 从保留时间校正方法对线性推移、非线性推移和时间延迟的校正效果方面探讨了保留时间校正方法的适用范围。认为一点法校正仅能校正线性推移；两点法可以校正时间延迟和线性推移，并能部分校正非线性推移。多点法使用分段线性逼近的方法对非线性推移有良好的校正效果。
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| 关 键 词： | 中药 色谱指纹图谱 保留时间 校正方法 相似度 |
| 收稿时间： | 2004-11-12 |
| 修稿时间： | 2004-11-122005-04-28 |
Retention Time Correction Method in the Similarity Calculation of the Chromatographic Fingerprints of Traditional Chinese Medicine |
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| Chai Yifeng,Luo Guoan,Qiao Shanlei,Zhu Zhenyu,Lu Feng,Wang Jianjun. Retention Time Correction Method in the Similarity Calculation of the Chromatographic Fingerprints of Traditional Chinese Medicine[J]. Chinese Journal of Analytical Chemistry, 2005, 33(11): 1599-1602 |
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| Authors: | Chai Yifeng Luo Guoan Qiao Shanlei Zhu Zhenyu Lu Feng Wang Jianjun |
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| Affiliation: | School of Pharmacy, Second Military Medical University, Shanghai 200433 ; Department of Chemistry, Tsinghua University, Belting 100084 |
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| Abstract: | Effects of different retention time correction formulae on linear shift, nonlinear shift and retention time delay are discussed. And the actual samples of Radix Salviae mihiorhizae were used to cheek the correctness of different correction formulae. Single-point formula deals well only with linear shift. Dual-point formula is suitable for the correction of nonlinear shift and retention time delay. Multi-point formula, depending on the segmented linear approximation, turns out to be effective in correcting the nonlinear shift. |
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| Keywords: | Chromatographic fingerprints traditional Chinese medicine retention time correction method similarity calculation |
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