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尿微量白蛋白的可见-近红外光谱检测
引用本文:Li G,Zhao Z,Liu R,Wang HQ,Lin L,Zhang BJ,Wu XR. 尿微量白蛋白的可见-近红外光谱检测[J]. 光谱学与光谱分析, 2011, 31(9): 2412-2415
作者姓名:Li G  Zhao Z  Liu R  Wang HQ  Lin L  Zhang BJ  Wu XR
作者单位:1. 天津大学精密测试技术及仪器国家重点实验室,天津,300072
2. 天津大学精密测试技术及仪器国家重点实验室,天津300072;天津市人民医院检验学部,天津300121
3. 天津师范大学物理与电子信息学院,天津,300387
基金项目:国家自然科学基金项目(60674111,30973964)资助
摘    要:尿微量白蛋白是临床上检测肾损伤最可靠的诊断指标.为实现尿微量白蛋白快速无试剂检测,本文采用多光程方式得到207例尿液样品可见-近红外双波段的多光程光谱,基于多光程光谱的非线性特性,获得更多样品成分含量的信息.在首先进行PLS建模的基础上,使用PLS-ANN建模方法引入非线性信息,对样本的可见-近红外波段多光程光谱与尿微...

关 键 词:尿微量白蛋白  近红外光谱  偏最小二乘  人工神经网络  多光程

Research on the measurement of urinary albumin by visible-near infrared spectroscopy
Li Gang,Zhao Zhe,Liu Rui,Wang Hui-Quan,Lin Ling,Zhang Bao-Ju,Wu Xiao-Rong. Research on the measurement of urinary albumin by visible-near infrared spectroscopy[J]. Spectroscopy and Spectral Analysis, 2011, 31(9): 2412-2415
Authors:Li Gang  Zhao Zhe  Liu Rui  Wang Hui-Quan  Lin Ling  Zhang Bao-Ju  Wu Xiao-Rong
Affiliation:LI Gang1,ZHAO Zhe1,LIU Rui1,2,WANG Hui-quan1,LIN Ling1,ZHANG Bao-ju3,WU Xiao-rong3 1.State Key Laboratory of Precision Measurement Technology and Instruments,Tianjin University,Tianjin 300072,China 2.Division of Inspection,Tianjin Union Medicine Center,Tianjin 300121,China 3.College of Physics & Electronic Information,Tianjin Normal University,Tianjin 300387,China
Abstract:The urinary albumin(UMALB) is the most reliable diagnostic indicator of renal injury in clinical.Attempting to realize the rapid and free reagent measurement of UMALB,the visible-near infrared multiple optical path length spectra of 207 urine samples were collected.By the nonlinear characteristics of multiple optical path length spectra,more information about the component of sample contents can be obtained.The PLS model of the spectra and UMALB was firstly established.Based on it,the PLS-ANN modeling metho...
Keywords:Urinary albumin  Near infrared spectroscopy  Partial least square(PLS)  Artificial neural network(ANN)  Multiple optical path length  
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