Lembehsterols A and B,novel sulfated sterols inhibiting thymidine phosphorylase,from the marine sponge Petrosia strongylata |
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| Authors: | Aoki Shunji Naka Yoshiharu Itoh Takuya Furukawa Tatsuhiko Rachmat Rachmaniar Akiyama Shin-ichi Kobayashi Motomasa |
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| Institution: | Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan. |
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| Abstract: | Lembehsterols A (1) and B (2), two novel sulfated sterols, were isolated from the marine sponge Petrosia strongylata. Both sterols showed inhibitory activity against thymidine phosphorylase, which is an enzyme related to angiogenesis in solid tumors. The structures of these sulfated sterols were established on the basis of chemical and physicochemical evidence. |
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