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Three-component Reaction of Aromatic Aldehyde, Malononitrile and Aliphatic Amine Leading to Different Pyridine Derivatives |
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| Authors: | CHEN Jiao MA Zhen and YAN Chao-guo |
| Institution: | College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. China |
| Abstract: | The three-component reaction of aromatic aldehyde,malononitrile and aliphatic amine in a mixed solvent of methanol and water exhibited very interesting molecular diversity and gave the derivatives of polysubstituted N-methyldihydropyridines,2-dialkylaminopyridines and 2-methoxypyridines as main products according to the structure of aliphatic amines used. |
| Keywords: | Multicomponent reaction Malononitrile Aldehyde Dihydropyridine Pyridine Aminopyridine |
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