New palladium(II) complexes with pyrazole ligands |
| |
| Authors: | Carolina V Barra Fillipe V Rocha Adelino V G Netto Regina C G Frem Antonio E Mauro Iracilda Z Carlos Sandra R Ananias Marcela B Quilles |
| |
| Institution: | 1.Departamento de Química Geral e Inorganica, Instituto de Química de Araraquara,UNESP-Univ Estadual Paulista,Araraquara,Brazil;2.Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara,UNESP-Univ Estadual Paulista,Araraquara,Brazil |
| |
| Abstract: | This study describes the synthesis, IR, 1H, and 13C{1H} NMR spectroscopic as well the thermal characterization of the new palladium(II) pyrazolyl complexes PdCl2(HmPz)2] 1, PdBr2(HmPz)2] 2, PdI2(HmPz)2] 3, Pd(SCN)2(HmPz)2] 4 {HmPz = 4-methylpyrazole}. The residues of the thermal decomposition were identified as Pd0 by X-ray powder diffraction. From the initial decomposition temperatures, the thermal stability of the complexes can be ordered
in the sequence: 1 > 2 > 4 ≈ 3. The cytotoxic activities of the complexes and the ligand were investigated against two murine cancer cell lines: mammary
adenocarcinoma (LM3) and lung adenocarcinoma (LP07) and compared to cisplatin under the same experimental conditions. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
