| 三种天然脱氧核苷的高效合成 |
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| 引用本文： | 季奇,黄飞,李金亮,孟继本. 三种天然脱氧核苷的高效合成[J]. 高等学校化学学报, 2006, 27(4): 666-668 |
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| 作者姓名： | 季奇 黄飞 李金亮 孟继本 |
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| 作者单位： | 1. 南开大学化学系, 天津 300071; 2. 上海迪塞诺生物医药有限公司, 上海 201203) |
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| 摘 要： | 本文以1-氯-2-脱氧-α-3,5-二-O-(对氯苯甲酰基)呋喃核糖(1)(以下简称氯代糖)为原料, 开发出可以适用于大规模工业生产的简单、 高效的合成上述三种天然核苷路线.
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| 关 键 词： | 核苷 合成 立体选择性, |
| 文章编号： | 0251-0790（2006）04-0666-03 |
| 收稿时间： | 2005-03-10 |
| 修稿时间： | 2005-03-10 |
Highly Efficient Synthesis of Three Natural Deoxynucleosides |
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| JI Qi,HUANG Fei,LI Jin-Liang,MENG Ji-Ben. Highly Efficient Synthesis of Three Natural Deoxynucleosides[J]. Chemical Research In Chinese Universities, 2006, 27(4): 666-668 |
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| Authors: | JI Qi HUANG Fei LI Jin-Liang MENG Ji-Ben |
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| Affiliation: | 1. Department of Chemistry, Nankai University, Tianjin 300071, China;2. Shanghai Desano Biomedical Company, Shanghai 201203, China |
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| Abstract: | Three natural deoxynucleosides were synthesized with a high stereoselectivity and good or excellent yield. In the preparation of 2′-deoxy-β-D-adenosine, glycosidations between 1-chloro-2-deoxy-3,5-di-O-(p-chlorobenzyl)-α-D erythro-pentofuranose and silylated adenine as well as adenine sodium salt were systematically studied. A simple synthesis route to prepare 2′-deoxy-β-D-adenosine without chromatography was developed, making 2 deoxy-β-D-adenosine readily accessible in an industrial scale. High efficient synthesis of 2′-deoxy-β-D-cytidine and 2′-deoxy-β-D-thymidine were also achieved without chromatography by glycosidations between 1-chloro-2-deoxy-3,5-di-O-(p-chlorobenzyl)-α-D-erythro-pentofuranose and silylated bases via the similar procedure. |
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| Keywords: | Nucleoside Synthesis Stereoselectivity |
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