Thermodynamic
investigations of sublimation, solubility and solvation of [4-(benzyloxy)-phenyl]acetic
acid |
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Authors: | S V Kurkov G L Perlovich W Zielenkiewicz |
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Institution: | (1) Institute of Solution Chemistry, Russian Academy of Sciences, Ivanovo, Russia, 15-3045;(2) Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland, 01-224 |
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Abstract: | Temperature
dependences of solubility, saturated vapour pressure and crystal heat capacity
of 4-(Benzyloxy)phenyl]acetic acid were determined. The solubility of this
compound was investigated in n-hexane,
buffered water solutions with pH 2.0 and 7.4 and n-octanol.
The enthalpy of sublimation and vaporization as well as the fusion temperature
were determined. Solvation and solubility processes have been analyzed. The
thermodynamics of transfer processes from one buffer to another (protonation
process), from buffers to 1-octanol (partitioning process), and from n-hexane to the applied solvents (specific interaction)
have been calculated and compared to those of other NSAIDs. The relevant shares
of specific and non-specific interactions in the process of solvation have
been investigated and discussed. |
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Keywords: | [4-(benzyloxy)phenyl]acetic acid DSC fusion heat capacity solubility solvation sublimation thermodynamic functions thermogravimetry transfer process vaporization water/octanol system |
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