| N-Alkoxyl Templates for Diastereoselective Pyrrolidine Synthesis |
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| 引用本文： | SongQingWANG OmarA.IBRAHIMI PanLI KangZHAO. N-Alkoxyl Templates for Diastereoselective Pyrrolidine Synthesis[J]. 中国化学快报, 2004, 15(1): 1-4 |
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| 作者姓名： | SongQingWANG OmarA.IBRAHIMI PanLI KangZHAO |
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| 作者单位： | [1]CollegeofPharmaceuticalsandBiotechnology,TianjinUniversity,Tianjin300072 [2]DepartmentofChemistry,NewYorkUniversity,NewYork,NY10003,USA |
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| 摘 要： | Intramolecular cyclization of N-alkoxyl amines are studied for the stereoselective preparation of 2, 4-disubstituted pyrrolidine derivatives. Reduction of oximes under acidic conditions by NaBH3CN afforded the corresponding nucleophilic hydroxylamine derivatives,which subsequently cyclized via SN2‘ mechanism to give the desired N-alkoxyl pyrrolidines.
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| 关 键 词： | 吡咯烷 合成 烷氧基化氮 羟胺 肟 |
N-Alkoxyl Templates for Diastereoselective Pyrrolidine Synthesis |
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| Song Qing WANG, Omar A. IBRAHIMI, Pan LI, Kang ZHAO College of Pharmaceuticals and Biotechnology,Tianjin University,Tianjin. N-Alkoxyl Templates for Diastereoselective Pyrrolidine Synthesis[J]. Chinese Chemical Letters, 2004, 15(1): 1-4 |
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| Authors: | Song Qing WANG Omar A. IBRAHIMI Pan LI Kang ZHAO College of Pharmaceuticals Biotechnology Tianjin University Tianjin |
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| Affiliation: | Song Qing WANG,1 Omar A. IBRAHIMI,2 Pan LI,2 * Kang ZHAO1* 1 College of Pharmaceuticals and Biotechnology,Tianjin University,Tianjin 300072 2 Department of Chemistry,New York University,New York,NY 10003,USA |
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| Abstract: | Intramolecular cyclization of N-alkoxyl amines are studied for the stereoselective preparation of 2, 4-disubstituted pyrrolidine derivatives. Reduction of oximes under acidic conditions by NaBH3CN afforded the corresponding nucleophilic hydroxylamine derivatives, which subsequently cyclized via SN2' mechanism to give the desired N-alkoxyl pyrrolidines. |
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| Keywords: | SN' reaction pyrrolidines oxime hydroxylamine. |
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